104987-11-3 Tacrolimus immunsuppressive Heißer Verkauf, hohe Qualität und bester Preis, , Sicherheitstransport, D
Modell Nr.
104987-11-3 Tacrolimus
Qualität
Hohe Qualität
Qualitätsanforderung
Strenge Qualitätskontrolle
Standard
usp/ep/BP/CP/ip/jp/WHO/intern
Kapazität
1000kg/Mon
Transportpaket
25kg/Drum/1000g/Bag/10g/Bag
Spezifikation
100% raw material
Warenzeichen
Widely
Herkunft
China
Produktionskapazität
1000kg/Mon
Referenzpreis
$ 13.50 - 45.00
Beschreibung
Produktbeschreibung
104987-11-3
Immunosuppressive
Tacrolimus
CAS:104987-11-3
MF:C44 H69 N O12
MW:804.02
EINECS:1308068-626-2
Tacrolimus, a hydrophobic macrocyclic lactone, was first isolated in 1985 from the fermentation broth of Streptomyces tsukubaensis, a soil microorganism found in the Tsukuba region of northern Japan. It has been in clinical use in Japan since 1993 and was approved in the US in April 1994 for the prophylaxis of organ rejection after liver transplantation. Tacrolimus is also effective in preventing graft rejection in heart, small bowel, and kidney transplants. Now tacrolimus has been used clinically in the treatment of rejection following transplantation with a variety of organs and also as an immunosuppressive agent in the therapy of autoimmune disorders[1].
Tacrolimus, displays similar, but more potent, immunosuppressive properties to cyclosporin, inhibiting cell-mediated and humoral immune responses. Through its interaction with a specific cytoplasmic immunophilin, tacrolimus inhibits calcium-dependent signal transduction pathways in T cells, thereby preventing transcription of a discrete. Tacrolimus interferes with a variety of exocytosis-related events in cells of haematopoietic lineage (basophils, neutrophils and mast cells), but at concentrations which suppress T cell proliferation, tacrolimus does not modify mononuclear phagocyte function. Tacrolimus displays hepatotrophic properties, stimulating hepatic regeneration following hepatectomy, and confers hepatoprotective and renoprotective effects against ischaemia/reperfusion injury. Tacrolimus has a direct glomeruloconstrictive effect and on subacute administration reduces renal perfusion and glomerular flow. Tacrolimus induced nephrotoxicity has variously been attributed to altered prostaglandin metabolism, lipid peroxidation of the plasma membrane, and enhanced endothelin secretion. In animal models of organ transplantation, tacrolimus has been shown to prolong survival of hepatic, renal, cardiac, small intestine, pancreatic and skin allografts, and to reverse cardiac and renal allograft rejection[1].
Tacrolimus is highly lipophilic and undergoes extensive tissue distribution. In blood, tacrolimus is sequestered by erythrocytes, with the result that plasma drug concentrations are approximately 10 to 30 times lower than whole blood concentrations. Tacrolimus is metabolized extensively in the liver, primarily by demethylation and hydroxylation, with less than 1 % of the parent compound being excreted unaltered in the bile and urine. Hepatic dysfunction is associated with elevated plasma concentrations of tacrolimus, prolongation of the plasma elimination half-life, and reduced plasma clearance.
Tacrolimus is primarily eliminated from the body in the bile by hepatic metabolism, and less than 1% of unchanged drug is excreted in the urine. Cytochrome P450 3A(CYP3A) mediates the bio-transformation of tacrolimus through the demethylation and hydroxylation of hepatic and intestinal CYP3A isoforms, and then tacrolimus is cleared through hepatic metabolism[2]. It is metabolized to at least 8 metabolites[3]. Four of them are major metabolites of varying immunosuppressive activity: 13-O-demethyl (M-I), 31-O-demethyl (M-II), 15-Odemethyl (M-III), and 12-hydroxyl (M-IV). M-I to M-IV are first-generation metabolites, formed directly from the parent drug. M-V to M-VIII are formed from the first-generation metabolites and are considered to be second-generation metabolites.
Chinese factory quality, spot delivery on the same day, express delivery in five days
Storage: keep away from light, sealed and stored in a cool and dry place
Immunosuppressive
Tacrolimus
CAS:104987-11-3
MF:C44 H69 N O12
MW:804.02
EINECS:1308068-626-2
Tacrolimus, a hydrophobic macrocyclic lactone, was first isolated in 1985 from the fermentation broth of Streptomyces tsukubaensis, a soil microorganism found in the Tsukuba region of northern Japan. It has been in clinical use in Japan since 1993 and was approved in the US in April 1994 for the prophylaxis of organ rejection after liver transplantation. Tacrolimus is also effective in preventing graft rejection in heart, small bowel, and kidney transplants. Now tacrolimus has been used clinically in the treatment of rejection following transplantation with a variety of organs and also as an immunosuppressive agent in the therapy of autoimmune disorders[1].
Tacrolimus, displays similar, but more potent, immunosuppressive properties to cyclosporin, inhibiting cell-mediated and humoral immune responses. Through its interaction with a specific cytoplasmic immunophilin, tacrolimus inhibits calcium-dependent signal transduction pathways in T cells, thereby preventing transcription of a discrete. Tacrolimus interferes with a variety of exocytosis-related events in cells of haematopoietic lineage (basophils, neutrophils and mast cells), but at concentrations which suppress T cell proliferation, tacrolimus does not modify mononuclear phagocyte function. Tacrolimus displays hepatotrophic properties, stimulating hepatic regeneration following hepatectomy, and confers hepatoprotective and renoprotective effects against ischaemia/reperfusion injury. Tacrolimus has a direct glomeruloconstrictive effect and on subacute administration reduces renal perfusion and glomerular flow. Tacrolimus induced nephrotoxicity has variously been attributed to altered prostaglandin metabolism, lipid peroxidation of the plasma membrane, and enhanced endothelin secretion. In animal models of organ transplantation, tacrolimus has been shown to prolong survival of hepatic, renal, cardiac, small intestine, pancreatic and skin allografts, and to reverse cardiac and renal allograft rejection[1].
Tacrolimus is highly lipophilic and undergoes extensive tissue distribution. In blood, tacrolimus is sequestered by erythrocytes, with the result that plasma drug concentrations are approximately 10 to 30 times lower than whole blood concentrations. Tacrolimus is metabolized extensively in the liver, primarily by demethylation and hydroxylation, with less than 1 % of the parent compound being excreted unaltered in the bile and urine. Hepatic dysfunction is associated with elevated plasma concentrations of tacrolimus, prolongation of the plasma elimination half-life, and reduced plasma clearance.
Tacrolimus is primarily eliminated from the body in the bile by hepatic metabolism, and less than 1% of unchanged drug is excreted in the urine. Cytochrome P450 3A(CYP3A) mediates the bio-transformation of tacrolimus through the demethylation and hydroxylation of hepatic and intestinal CYP3A isoforms, and then tacrolimus is cleared through hepatic metabolism[2]. It is metabolized to at least 8 metabolites[3]. Four of them are major metabolites of varying immunosuppressive activity: 13-O-demethyl (M-I), 31-O-demethyl (M-II), 15-Odemethyl (M-III), and 12-hydroxyl (M-IV). M-I to M-IV are first-generation metabolites, formed directly from the parent drug. M-V to M-VIII are formed from the first-generation metabolites and are considered to be second-generation metabolites.
Chinese factory quality, spot delivery on the same day, express delivery in five days
Storage: keep away from light, sealed and stored in a cool and dry place
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