Product Name: Rivaroxaban
Synonyms: (S)-Rivaroxaban;(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiophene-2-carbox;RIVAROXABAN STAGE-IV [5-CHLORO-N-({5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-1,3-OXAZOLIDIN-5-YL}-METHYL)-2(AS PER INV;5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide;BAY 59-7939;Rivaroxaban Isomer;Rivaroxaban;5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide
CAS: 366789-02-8
MF: C19H18ClN3O5S
MW: 435.88
EINECS: 685-132-2
Melting point: 228-229°C
Boiling point: 732.6±60.0 °C
Density: 1.460±0.06 g/cm3
Storage temp.: Store at RT
Appearance: Off-White Powder
Description:
Venous thromboembolism continues to be a major health concern despite conventional anticoagulation therapies. Rivaroxaban is a recent market introduction that directly inhibits FXa with high potency (Ki=0.4 nM; IC50=0.7 nM) and selectivity>10,000-fold over other related serine (thrombin, trypsin, plasmin, FVIIa, FIXa, FXIa, urokinase, and activated protein C). From the X-ray crystal structure, the central oxazolidinone moiety anchors the drug through two hydrogen bonds to Gly219 and directs the morpholinone group into the S4 pocket and the chlorothiophene portion into the S1 pocket. These key components may be coupled together synthetically by a couple of routes. Condensation of 3-morpholinone with 4-fluoronitrobenzene followed by catalytic hydrogenation provides N-(p-aminophenyl)morpholinone for subsequent reaction with (S)-2-(phthalimidomethyl)oxirane. With establishment of the aminoalcohol adduct, cyclization with 1,1′-carbonyldiimidazole generates the central oxazolidinone. Deprotection and acylation with 5-chlorothiophene-2-carbonyl chloride affords rivaroxaban.
Uses:
Rivaroxaban is recommended as an option for treating pulmonary embolism and preventing recurrent deep vein thrombosis and pulmonary embolism in adults.
1. Rivaroxaban (Xarelto, Bayer) is indicated for the 'treatment of deep vein thrombosis and pulmonary embolism, and prevention of recurrent deep vein thrombosis and pulmonary embolism in adults'. For the initial treatment of acute pulmonary embolism, the recommended dosage of rivaroxaban is 15 mg twice daily for the first 21 days followed by 20 mg once daily for continued treatment and prevention of recurrent venous thromboembolism.
2. Non-Valvular Atrial Fibrillation (NVAF)* to prevent stroke & systemic embolism.
3. Acute VTE treatment & prevention of recurrent VTE [for deep vein thrombosis (DVT) and pulmonary embolism (PE)].
4. Prevention of venous thromboembolic events (VTE) in elective total hip or knee replacement surgery (THR, TKR).

1. Inner double plastic bags----25kg/Fiber drum (36*36*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags---5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags---1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
TRANSPORT:
BY SEA
BY AIRPORT
BY EXPRESS


Hebei Guanjin Technology Co., Ltd. It was founded in 2023, located in Xingtai, Hebei Province, which is specialized in the research of production and trade of plastic material and pharmaceutical intermediate. Our products have spread over more than 50 countries in the world, Most of the products produced and sold are exported abroad, and it is well-received in all around the word for its excellent quality. At the same time in case to maintain good relations of cooperation with domestic manufactures, we actively develop new products, new customers and constantly meet the needs of customers at home and abroad. We sincerely welcome more clients to cooperate with us.

1. We have our own factory and produce our own research and development products.
2.The quality of our products is guaranteed and the price is favorable
3.We are relatively close to Tianjin Port, and the delivery is more convenient
4. We can customize according to customer's needs
Q1: Are you a manufacturer or trade company?
A: We are a manufacturer for Powder Coating and Plastic Masterbatches products over 10 years.
OEM & ODM are available.
Q2: Can I get a sample before order in bulk? What is your MOQ ?
A: Yes, support sample order.
Q3:What is the lead time?
A: Generally 5-20 days(based on quantity).
Q4:Where is your loading port?
A: Tianjin Port, In China.
Q5.What is the shipping method?
A: It could be shipped by sea,by air or by express(EMS,UPS,DHL,TNT,FEDEX and ect).
Please confirm with us before placing orders.
Q6:What are your payments terms?
A: T/T, PayPal, Western Union or by Alibaba Trade Assurance
Q7.How do you make our business long-term and good relationship?
A: 1. We keep good quality and competitive price to ensure our customers' benefit;
2. We respect every customer as our friend and we sincerely do business and make friends with them, no matter where they come from.