Description | Fexofenadine is a histamine H 1 receptor antagonist (K i = 10 nM). It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine (Item No. 23092). Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells. Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS; Item No. 23250). |
Chemical Properties | White Crystalline powder |
Uses | A metabolite of of terfenadine, a H1-Histamine receptor antagonist |
Uses | The active metabolite of Terfenadine (T114500), a H1-histamine receptor antagonist. |
Uses | Antihistaminic;histamine H1-receptor antagonist |
Uses | Fexofenadine is a non-sedating antihistamine that selectively antagonizes the histamine H1 receptor with a Ki value of 10 nM and exhibits anti-inflammatory effects. It is devoid of central nervous system effects in part because it is a good substrate for the P-glycoprotein efflux pump situated within the blood-brain barrier.[Cayman Chemical] |
Uses | Fexofenadine hydrochloride is used as an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist. |