467426-54-6 Plecanatide Used in The Treatment of Chronic Idiopathic Constipation and Irritable bowl Syndrome with Constipation

Model NO.
467426-54-6
Standard
USP/Ep/Bp/Cp/IP/Jp/Who/in-House
Capacity
1000kg/Mon
Transport Package
25kg/Drum/1000g/Bag/10g/Bag
Specification
100% raw material
Trademark
Widely
Origin
China
Production Capacity
1000kg/Mon
Reference Price
$ 13.50 - 45.00
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Product Description

467426-54-6 Plecanatide Used in The Treatment of Chronic Idiopathic Constipation and Irritable bowl Syndrome with Constipation
467426-54-6 Plecanatide Used in The Treatment of Chronic Idiopathic Constipation and Irritable bowl Syndrome with Constipation
Uses Plecanatide is used in the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation. It works as a laxative by drawing water in to the gastrointestinal tract thereby softening stool and encouraging its natural passage.
Enzyme inhibitor This uroguanylin analogue (FW = 1681.90 g/mol; CAS 467426-54-6), also known by the codename SP-304, binds to and activates guanylate cyclase-C (GC-C) receptors (EC50 ≈ 0.3 μM) expressed on the epithelial cells lining turn sequentially activates protein kinase G-II and the chloride channel known as the Cystic Fibrosis Transmembrane-conductance Regulator (CFTR) to regulate ion and fluid transport, to promote epithelial cell homeostasis, and to maintain barrier function in the GI mucosa. Plecanatide is a hexadecapeptide that is structurally identical to uroguanylin, except for an glutamate substitution at position-3. Oral treatment with plecanatide at a dose range between 0.05-2.5 mg/kg per day is as effective as once-daily treatment with 5-amino salicylic acid (100 mg/kg) or sulfasalazine (80 mg/kg). Amelioration of colitis by the treatment with plecanatide or dolcanatide was not dose-dependent, most likely due to saturation of available GC-C receptors.
467426-54-6 Plecanatide Used in The Treatment of Chronic Idiopathic Constipation and Irritable bowl Syndrome with Constipation
467426-54-6 Plecanatide Used in The Treatment of Chronic Idiopathic Constipation and Irritable bowl Syndrome with Constipation
Hubei weideli Chemical Reagent Co., Ltd., located in Wuhan East Lake New Technology Development Zone, is a manufacturing supplier focusing on reagent products for scientific research, and its business scope includes the manufacturing of special chemical products; Disinfectant production; Sales of special chemical products; Disinfectant sales; Research and development of biological feed; Research and development of bio based materials technology; Research and development of biochemical products technology; Technical services, technical development, technical consultation, technical exchange, technology transfer and technology promotion; Sales of instruments and meters; Sales of daily glass products; Sales of technical glass products; Sales of electronic special materials; Technology import and export; Import and export of goods; Veterinary drug management; Production of disinfection products for the prevention and treatment of infectious diseases.

The company has gradually established extensive cooperation with scientific research institutions in Colleges and universities and powerful enterprises to lay a solid foundation for technological production; At the same time, we will recruit talents all over the country and keep them fresh and energetic; With more than ten years of experience and accumulation in the industry, the company further improves its market competitiveness and strengthens its support to customers.

With the help of modern ERP system, the company provides customers with accurate quotation and inventory information in time. It has a warehouse base and Laboratory of more than 1000 square meters in Jiangxia District, Wuhan. The system inventory products can be ordered on the same day, and the order number is given on the same day of delivery. The information can be queried online, followed up in real time, and customer service provides after-sales support services.

Hubei weideli Chemical Reagent Co., Ltd. is committed to scientific research.


I. Do you always have this products in stock?
Our company has more than 1000 kinds of products in stock. We usually have them 
in stock. We can show you the information, forms or pictures of our warehouse 
at any time. If the stock is insufficient, our company will replenish them as 
soon as possible according to the ERP system.

2. What certificates and documents do you offer?
According to the situation of products, we can provide COA, NMR, LC, MS, 
synthesis process, MQA, MSDS, etc

3. Why should I choose you?
Stock in stock and deliver in time
Reasonable price
Product technology and data support
Professional sales team
Perfect pre-sale and after-sale service

4. Can I get best price from you?
We don* t pursue expensive profits
We always try to give best offer
You can also enjoy fun of bargaining

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CHANHXETAI.VN, 2023